1 Vertex Pharmaceuticals Incorporated VRTX $138.61B $546.12 −2.12% $11.84 US 2 Regeneron Pharmaceuticals, Inc. REGN $85.27B $827.72 −1.87% $15.75 US 3 CSL Limited CSL.AX $59.76B $124.78 −0.76% $0.95 AU 4 Moderna, Inc. MRNA $57.75B $145.55 −2.23% $3.32 US 5 Samsung Biologics Co.,Ltd. 207940.KS $50.23B $1,085.04 +1.31% $14.06 KR 6 Lonza Group AG LONN.SW $48.45B $693.73 −0.95% $6.67 CH 7 UCB S.A. UCB.BR $46.87B $246.14 +0.62% $1.51 BE 8 Revolution Medicines, Inc. RVMD $44.65B $210.02 −0.40% $0.85 US 9 BeOne Medicines Ltd. Class A 688235.SS $41.30B $39.49 −2.20% $0.89 CH 10 BeOne Medicines AG ONC $38.28B $358.26 −1.22% $4.42 CH 11 Alnylam Pharmaceuticals, Inc. ALNY $35.61B $266.11 +0.61% $1.61 US 12 Celltrion, Inc. 068270.KS $31.62B $137.89 −0.96% $1.33 KR 13 Insmed Incorporated INSM $27.37B $126.29 −0.31% $0.39 US 14 BioNTech SE BNTX $26.06B $103.76 +0.86% $0.88 DE 15 WuXi Biologics (Cayman) Inc. WXIBF $25.79B $6.23 +0.00% $0.00 CN 16 Incyte Corporation INCY $25.69B $126.75 −0.98% $1.25 US 17 Innovent Biologics, Inc. IVBXF $22.82B $13.11 +2.10% $0.27 CN 18 United Therapeutics Corporation UTHR $20.70B $487.61 −0.54% $2.63 US 19 Genmab A/S GMAB $20.63B $33.60 −2.35% $0.81 DK 20 Ascendis Pharma A/S ASND $16.80B $270.56 −0.21% $0.56 DK 21 Neurocrine Biosciences, Inc. NBIX $15.65B $155.64 −1.71% $2.71 US 22 Jazz Pharmaceuticals plc JAZZ $15.50B $246.81 −0.30% $0.75 IE 23 Exelixis, Inc. EXEL $14.83B $59.01 −0.20% $0.12 US 24 Alteogen Inc. 196170.KQ $14.73B $211.68 −0.87% $1.85 KR 25 BridgeBio Pharma, Inc. BBIO $14.66B $74.84 −0.76% $0.57 US 26 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. 6990.HK $14.59B $62.55 +0.20% $0.13 CN 27 Summit Therapeutics Inc. SMMT $14.04B $17.61 +2.77% $0.47 US 28 Halozyme Therapeutics, Inc. HALO $13.07B $110.19 −0.51% $0.57 US 29 BioMarin Pharmaceutical Inc. BMRN $12.86B $66.53 +0.15% $0.10 US 30 Madrigal Pharmaceuticals, Inc. MDGL $12.50B $541.08 −0.28% $1.53 US 31 Arrowhead Pharmaceuticals, Inc. ARWR $12.16B $86.34 −0.17% $0.15 US 32 Haisco Pharmaceutical Group Co., Ltd. 002653.SZ $11.47B $10.24 −0.66% $0.07 CN 33 Bio-Techne Corporation TECH $11.34B $72.43 −0.03% $0.02 US 34 Akeso, Inc. 9926.HK $11.26B $12.24 −5.14% $0.66 CN 35 Axsome Therapeutics, Inc. AXSM $10.64B $206.68 −0.80% $1.67 US 36 Krystal Biotech, Inc. KRYS $10.56B $358.24 −3.56% $13.23 US 37 RemeGen Co. Ltd. Class A 688331.SS $10.12B $18.29 −1.20% $0.22 CN 38 Sichuan Kelun Pharmaceutical Co., Ltd. Class A 002422.SZ $9.85B $6.19 −0.91% $0.06 CN 39 Praxis Precision Medicines, Inc. PRAX $9.81B $351.81 −0.94% $3.34 US 40 Kymera Therapeutics, Inc. KYMR $9.66B $117.39 +0.09% $0.11 US 41 Ionis Pharmaceuticals, Inc. IONS $9.65B $58.09 −0.07% $0.04 US 42 Protagonist Therapeutics, Inc. PTGX $9.37B $145.72 −2.07% $3.08 US 43 Financière de Tubize S.A. TUB.BR $9.26B $207.93 +0.17% $0.35 BE 44 Pharmaron Beijing Co., Ltd. 300759.SZ $9.08B $6.15 +0.17% $0.01 CN 45 Vaxcyte, Inc. PCVX $8.83B $61.16 −0.02% $0.01 US 46 Genscript Biotech Corporation 1548.HK $8.64B $3.95 −1.46% $0.06 HK 47 TG Therapeutics, Inc. TGTX $8.57B $55.99 −1.28% $0.72 US 48 ImmunityBio, Inc. IBRX $8.46B $8.08 −1.34% $0.11 US 49 Abivax S.A. ABVX $8.43B $114.79 +0.66% $0.75 FR 50 Apogee Therapeutics, Inc. APGE $8.36B $135.07 +0.00% $0.00 US 51 Asymchem Laboratories (Tianjin) Co., Ltd. 002821.SZ $8.27B $24.83 +2.20% $0.53 CN 52 10x Genomics, Inc. TXG $7.95B $62.65 −0.90% $0.57 US 53 Twist Bioscience Corporation TWST $7.77B $124.72 −3.10% $3.99 US 54 Belite Bio, Inc BLTE $7.76B $193.61 +13.16% $22.52 US 55 Spyre Therapeutics, Inc. SYRE $7.73B $88.98 +1.98% $1.73 US 56 Shanghai Allist Pharmaceuticals Co., Ltd. 688578.SS $7.25B $16.10 −2.25% $0.37 CN 57 ALK-Abelló A/S ALK-B.CO $7.12B $32.13 −0.96% $0.31 DK 58 Bachem Holding AG BANB.SW $7.09B $94.59 −0.65% $0.62 CH 59 Caris Life Sciences, Inc. CAI $7.09B $25.07 −0.99% $0.25 US 60 Rhythm Pharmaceuticals, Inc. RYTM $7.05B $102.74 −2.05% $2.15 US 61 Scholar Rock Holding Corporation SRRK $6.63B $55.33 −1.09% $0.61 US 62 Samsung Epis Holdings 0126Z0.KS $6.63B $266.45 +1.12% $2.96 KR 63 RemeGen Co., Ltd. REGMF $6.16B $10.93 +0.00% $0.00 CN 64 Mirum Pharmaceuticals, Inc. MIRM $6.15B $100.90 +0.27% $0.27 US 65 Travere Therapeutics, Inc. TVTX $6.07B $65.28 −1.89% $1.26 US 66 Cogent Biosciences, Inc. COGT $5.94B $34.76 −0.54% $0.19 US 67 PTC Therapeutics, Inc. PTCT $5.78B $69.30 −2.94% $2.10 US 68 Xenon Pharmaceuticals Inc. XENE $5.78B $59.75 −1.08% $0.65 CA 69 Ligand Pharmaceuticals Incorporated LGND $5.72B $285.60 −1.43% $4.14 US 70 Biocon Limited BIOCON.NS $5.66B $4.14 −1.51% $0.06 IN 71 Erasca, Inc. ERAS $5.62B $16.19 −0.43% $0.07 US 72 Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd 688336.SS $5.60B $6.24 −0.62% $0.04 CN 73 Oruka Therapeutics, Inc. ORKA $5.58B $92.51 +1.67% $1.52 US 74 Anthem Biosciences Ltd. ANTHEM.NS $5.55B $9.88 −0.06% $0.01 IN 75 Hangzhou Tigermed Consulting Co., Ltd 300347.SZ $5.42B $7.34 −1.48% $0.11 CN 76 3SBio Inc. TRSBF $5.38B $2.15 +0.00% $0.00 — CN 77 Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. 603392.SS $5.17B $4.09 −0.83% $0.03 CN 78 Definium Therapeutics, Inc. DFTX $5.06B $38.09 +0.24% $0.09 US 79 Shanghai Junshi Biosciences Co., Ltd. 688180.SS $4.97B $4.88 −2.15% $0.11 CN 80 SK Biopharmaceuticals Co., Ltd. 326030.KS $4.93B $62.91 −1.85% $1.18 KR 81 Shanghai RAAS Blood Products Co., Ltd. 002252.SZ $4.85B $0.74 +0.41% $0.00 CN 82 ACADIA Pharmaceuticals Inc. ACAD $4.80B $28.02 +0.57% $0.16 US 83 Chongqing Zhifei Biological Products Co., Ltd. 300122.SZ $4.74B $1.98 +0.23% $0.00 CN 84 Celcuity Inc. CELC $4.67B $95.70 −0.76% $0.73 US 85 Edgewise Therapeutics, Inc. EWTX $4.63B $43.07 +2.67% $1.12 US 86 Suzhou Zelgen Biopharmaceuticals Co., Ltd. 688266.SS $4.62B $17.46 −0.70% $0.12 CN 87 Lin BioScience, Inc. 6696.TWO $4.57B $5.51 +19.93% $0.92 TW 88 Shanghai Henlius Biotech, Inc. 2696.HK $4.54B $8.36 −6.49% $0.58 CN 89 Dyne Therapeutics, Inc. DYN $4.53B $24.28 −2.69% $0.67 US 90 Changchun High-Tech Industries (Group) Inc. 000661.SZ $4.44B $10.89 −0.90% $0.10 CN 91 Enliven Therapeutics, Inc. ELVN $4.24B $59.32 −0.55% $0.33 US 92 Veradermics, Incorporated MANE $4.12B $98.51 +0.78% $0.76 US 93 Viking Therapeutics, Inc. VKTX $4.07B $34.87 +2.62% $0.89 US 94 Telix Pharmaceuticals Limited TLX $4.04B $11.94 +1.70% $0.20 AU 95 Legend Biotech Corporation LEGN $3.98B $21.52 −1.06% $0.23 US 96 Iovance Biotherapeutics, Inc. IOVA $3.92B $8.79 +1.03% $0.09 US 97 XtalPi Holdings Ltd 2228.HK $3.92B $0.91 −2.59% $0.02 CN 98 Tarsus Pharmaceuticals, Inc. TARS $3.91B $90.78 +9.10% $7.57 US 99 Adaptive Biotechnologies Corporation ADPT $3.89B $24.28 −1.18% $0.29 US 100 Amylyx Pharmaceuticals, Inc. AMLX $3.79B $34.10 +0.41% $0.14 US 101 IDEAYA Biosciences, Inc. IDYA $3.79B $39.86 −0.28% $0.11 US 102 Arcus Biosciences, Inc. RCUS $3.73B $29.66 −1.56% $0.47 US 103 Tango Therapeutics, Inc. TNGX $3.67B $22.52 −1.05% $0.24 US 104 Beijing Tiantan Biological Products Co., Ltd. 600161.SS $3.61B $1.83 −0.24% $0.00 CN 105 Camurus AB CAMX.ST $3.60B $60.54 −1.36% $0.84 SE 106 Hualan Biological Engineering Inc. 002007.SZ $3.55B $1.94 +0.08% $0.00 CN 107 InSilico Medicine Cayman TopCo 3696.HK $3.52B $6.08 −2.26% $0.14 HK 108 AbCellera Biologics Inc. ABCL $3.49B $11.43 −1.21% $0.14 CA 109 Xiamen Amoytop Biotech Co., Ltd. 688278.SS $3.47B $8.51 +0.28% $0.02 CN 110 Zealand Pharma A/S ZEAL.CO $3.28B $47.94 +1.02% $0.48 DK 111 HLB Co., Ltd. 028300.KQ $3.24B $24.39 −2.37% $0.59 KR 112 Hebei Changshan Biochemical Pharmaceutical Co., Ltd. 300255.SZ $3.22B $3.50 +1.42% $0.05 CN 113 BioArctic AB BIOA-B.ST $3.07B $34.65 −0.78% $0.27 SE 114 Beam Therapeutics Inc. BEAM $3.05B $29.66 +0.68% $0.20 US 115 Disc Medicine, Inc. IRON $3.04B $79.23 −0.18% $0.14 US 116 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. 2315.HK $3.00B $7.40 −4.29% $0.33 CN 117 Arcutis Biotherapeutics, Inc. ARQT $2.99B $23.90 +1.01% $0.24 US 118 Zai Lab Limited ZLAB $2.96B $26.23 −2.85% $0.77 CN 119 MBX Biosciences, Inc. Common Stock MBX $2.94B $61.72 +0.49% $0.30 US 120 Keymed Biosciences Inc. 2162.HK $2.93B $9.96 −2.07% $0.21 CN 121 Structure Therapeutics Inc. GPCR $2.73B $47.34 +0.00% $0.00 US 122 Nurix Therapeutics, Inc. NRIX $2.71B $26.14 +3.24% $0.82 US 123 Viridian Therapeutics, Inc. VRDN $2.60B $22.92 −0.17% $0.04 US 124 SELLAS Life Sciences Group, Inc. SLS $2.58B $13.86 +1.17% $0.16 US 125 Vera Therapeutics, Inc. VERA $2.58B $35.89 +2.57% $0.90 US 126 Immunome, Inc. IMNM $2.56B $26.76 −1.47% $0.40 US 127 BioCryst Pharmaceuticals, Inc. BCRX $2.53B $9.96 −1.29% $0.13 US 128 Precigen, Inc. PGEN $2.53B $7.10 −0.56% $0.04 US 129 LigaChem Biosciences Inc. 141080.KQ $2.49B $68.31 +0.33% $0.22 KR 130 Bavarian Nordic A/S BAVA.CO $2.49B $32.88 −1.86% $0.62 DK 131 Mineralys Therapeutics, Inc. MLYS $2.49B $28.21 −0.21% $0.06 US 132 OmniAb, Inc. OABIW $2.48B $0.39 +0.98% $0.00 US 133 Pharvaris N.V. PHVS $2.46B $35.25 −1.15% $0.41 CH 134 Trevi Therapeutics, Inc. TRVI $2.45B $17.26 +1.17% $0.20 US 135 Harmony Biosciences Holdings, Inc. HRMY $2.45B $42.25 +0.93% $0.39 US 136 Sarepta Therapeutics, Inc. SRPT $2.38B $22.50 −2.13% $0.49 US 137 Sinocelltech Group Limited 688520.SS $2.38B $5.05 −1.85% $0.10 CN 138 Nuvation Bio Inc. NUVB $2.36B $6.81 +0.59% $0.04 US 139 Biohaven Ltd. BHVN $2.36B $15.69 −1.07% $0.17 US 140 Ocular Therapeutix, Inc. OCUL $2.33B $10.64 +0.00% $0.00 US 141 InnoCare Pharma Limited INCPF $2.32B $1.55 +0.00% $0.00 — CN 142 Palvella Therapeutics, Inc. PVLA $2.26B $157.24 +1.14% $1.77 US 143 Mesoblast Limited MESO $2.25B $17.32 +1.05% $0.18 AU 144 ADMA Biologics, Inc. ADMA $2.23B $9.62 +0.42% $0.04 US 145 Kodiak Sciences Inc. KOD $2.21B $35.36 −2.75% $1.00 US 146 SK bioscience Co.,Ltd. 302440.KS $2.18B $27.83 −0.79% $0.22 KR 147 UroGen Pharma Ltd. URGN $2.15B $44.09 −1.76% $0.79 US 148 Zymeworks Inc. ZYME $2.15B $29.19 −2.37% $0.71 US 149 Alamar Biosciences, Inc. ALMR $2.13B $30.80 +0.75% $0.23 US 150 Nektar Therapeutics NKTR $2.13B $74.19 −2.85% $2.18 US