1 Vertex Pharmaceuticals Incorporated VRTX $121.95B $480.50 −1.06% $5.15 US 2 Regeneron Pharmaceuticals, Inc. REGN $69.25B $672.15 −0.67% $4.54 US 3 UCB S.A. UCB.BR $51.81B $272.18 −0.54% $1.49 BE 4 Lonza Group AG LONN.SW $48.88B $699.89 −0.49% $3.47 CH 5 Samsung Biologics Co.,Ltd. 207940.KS $44.12B $953.10 +4.83% $43.94 KR 6 CSL Limited CSL.AX $40.61B $84.80 −1.37% $1.18 AU 7 BeOne Medicines Ltd. Class A 688235.SS $40.01B $38.26 −0.32% $0.12 CH 8 Revolution Medicines, Inc. RVMD $38.35B $180.39 −3.10% $5.77 US 9 Alnylam Pharmaceuticals, Inc. ALNY $36.40B $272.67 +1.94% $5.20 US 10 BeOne Medicines AG ONC $33.19B $310.58 −0.46% $1.45 CH 11 Celltrion, Inc. 068270.KS $26.97B $117.62 +0.81% $0.95 KR 12 Moderna, Inc. MRNA $23.60B $59.49 −3.77% $2.33 US 13 BioNTech SE BNTX $23.31B $92.16 +0.74% $0.68 DE 14 Insmed Incorporated INSM $23.20B $107.02 −1.20% $1.30 US 15 Incyte Corporation INCY $23.10B $115.65 −1.36% $1.60 US 16 Innovent Biologics, Inc. 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AXSM $11.41B $221.64 −3.63% $8.36 US 31 Bio-Techne Corporation TECH $11.22B $71.64 −0.67% $0.48 US 32 Sichuan Kelun Pharmaceutical Co., Ltd. Class A 002422.SZ $10.89B $6.84 −3.28% $0.23 CN 33 Akeso, Inc. 9926.HK $10.88B $11.83 −0.64% $0.08 CN 34 Summit Therapeutics Inc. SMMT $10.48B $13.50 −2.24% $0.31 US 35 Financière de Tubize S.A. TUB.BR $10.36B $232.84 −1.17% $2.74 BE 36 Arrowhead Pharmaceuticals, Inc. ARWR $10.09B $71.65 −3.57% $2.65 US 37 Krystal Biotech, Inc. KRYS $10.00B $339.22 −4.41% $15.64 US 38 Alteogen Inc. 196170.KQ $9.91B $185.21 +1.67% $3.04 KR 39 Cytokinetics, Incorporated CYTK $9.84B $79.11 −1.33% $1.07 US 40 Abivax S.A. ABVX $9.66B $131.50 −3.77% $5.15 FR 41 Halozyme Therapeutics, Inc. HALO $9.14B $77.09 −0.93% $0.72 US 42 Nuvalent, Inc. NUVL $9.13B $123.96 +0.00% $0.00 US 43 Ionis Pharmaceuticals, Inc. IONS $8.75B $52.95 −2.65% $1.44 US 44 Alkermes plc ALKS $8.62B $51.72 −1.90% $1.00 IE 45 Shanghai Allist Pharmaceuticals Co., Ltd. 688578.SS $8.39B $18.64 −1.16% $0.22 CN 46 Apogee Therapeutics, Inc. APGE $8.30B $134.15 +0.11% $0.15 US 47 TG Therapeutics, Inc. TGTX $8.26B $53.96 −1.66% $0.91 US 48 Immunovant, Inc. IMVT $8.20B $39.92 −0.84% $0.34 US 49 Asymchem Laboratories (Tianjin) Co., Ltd. 002821.SZ $8.14B $24.45 +1.65% $0.40 CN 50 ALK-Abelló A/S ALK-B.CO $8.05B $36.35 −1.00% $0.37 DK 51 Vaxcyte, Inc. PCVX $8.01B $55.50 −1.25% $0.70 US 52 ImmunityBio, Inc. IBRX $7.85B $7.50 −2.41% $0.19 US 53 Rhythm Pharmaceuticals, Inc. RYTM $7.17B $104.60 −1.88% $2.00 US 54 RemeGen Co., Ltd. REGMF $6.79B $12.05 +0.00% $0.00 CN 55 Cogent Biosciences, Inc. COGT $6.54B $38.30 −2.00% $0.78 US 56 PTC Therapeutics, Inc. PTCT $6.47B $78.01 −0.74% $0.58 US 57 Praxis Precision Medicines, Inc. PRAX $6.44B $304.43 −3.17% $9.98 US 58 Samsung Epis Holdings 0126Z0.KS $6.37B $255.85 +1.61% $4.06 KR 59 Biocon Limited BIOCON.BO $6.20B $4.53 −0.17% $0.01 IN 60 Belite Bio, Inc BLTE $6.13B $152.84 +1.84% $2.76 US 61 Scholar Rock Holding Corporation SRRK $6.07B $50.66 −4.16% $2.20 US 62 Ligand Pharmaceuticals Incorporated LGND $5.89B $293.99 −3.10% $9.40 US 63 Spyre Therapeutics, Inc. SYRE $5.88B $97.33 −2.89% $2.90 US 64 Mirum Pharmaceuticals, Inc. MIRM $5.85B $116.62 −1.88% $2.24 US 65 Erasca, Inc. ERAS $5.85B $18.82 −1.83% $0.35 US 66 Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd 688336.SS $5.67B $6.33 −2.73% $0.18 CN 67 Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. 603392.SS $5.40B $4.27 −1.27% $0.05 CN 68 Shanghai Junshi Biosciences Co., Ltd. 688180.SS $5.38B $5.28 −0.45% $0.02 CN 69 3SBio Inc. TRSBF $5.38B $2.15 +0.00% $0.00 CN 70 Suzhou Zelgen Biopharmaceuticals Co., Ltd. 688266.SS $5.36B $20.25 −1.23% $0.25 CN 71 Hangzhou Tigermed Consulting Co., Ltd 300347.SZ $5.24B $7.10 −2.18% $0.16 CN 72 Xenon Pharmaceuticals Inc. XENE $5.21B $66.04 −3.25% $2.22 CA 73 Travere Therapeutics, Inc. TVTX $5.16B $55.47 −2.19% $1.24 US 74 Shanghai RAAS Blood Products Co., Ltd. 002252.SZ $5.03B $0.76 −1.34% $0.01 CN 75 Definium Therapeutics, Inc. DFTX $4.67B $42.80 −3.36% $1.49 US 76 Anthem Biosciences Ltd. ANTHEM.NS $4.62B $8.22 +1.87% $0.15 IN 77 Chongqing Zhifei Biological Products Co., Ltd. 300122.SZ $4.51B $1.88 −0.31% $0.01 CN 78 Veradermics, Incorporated MANE $4.43B $106.04 −4.74% $5.28 US 79 Caris Life Sciences, Inc. CAI $4.40B $15.56 −5.64% $0.93 US 80 ACADIA Pharmaceuticals Inc. ACAD $4.30B $25.09 −1.99% $0.51 US 81 Legend Biotech Corporation LEGN $4.29B $23.21 +4.27% $0.95 US 82 Celcuity Inc. CELC $4.29B $87.99 −0.44% $0.39 US 83 Simcere Pharmaceutical Group Limited 2096.HK $4.27B $1.66 +0.15% $0.00 CN 84 Viking Therapeutics, Inc. VKTX $4.22B $36.38 −1.89% $0.70 US 85 Edgewise Therapeutics, Inc. EWTX $4.18B $38.81 −2.39% $0.95 US 86 SK Biopharmaceuticals Co., Ltd. 326030.KS $4.14B $52.86 +1.82% $0.95 KR 87 Shanghai Henlius Biotech, Inc. 2696.HK $4.01B $7.38 +0.09% $0.01 CN 88 Genscript Biotech Corporation GNNSF $3.98B $1.82 +21.33% $0.32 CN 89 Dyne Therapeutics, Inc. DYN $3.88B $23.45 −1.22% $0.29 US 90 Catalyst Pharmaceuticals, Inc. CPRX $3.85B $31.49 +0.00% $0.00 US 91 Hebei Changshan Biochemical Pharmaceutical Co., Ltd. 300255.SZ $3.84B $4.18 −6.09% $0.27 CN 92 Beijing Tiantan Biological Products Co., Ltd. 600161.SS $3.70B $1.87 −1.48% $0.03 CN 93 Enliven Therapeutics, Inc. ELVN $3.69B $51.67 −2.88% $1.53 US 94 Denali Therapeutics Inc. 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