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| APGE | Apogee Therapeutics, Inc. | $135.07 | $8.4B |
| SRRK | Scholar Rock Holding Corporation | $55.33 | $6.6B |
| CGON | CG Oncology Inc. | $74.67 | $6.6B |
| CNTA | Centessa Pharmaceuticals plc | $40.50 | $6.3B |
| TVTX | Travere Therapeutics, Inc. | $65.28 | $6.1B |
| CELC | Celcuity Inc. | $95.70 | $4.7B |
| LEGN | Legend Biotech Corporation | $21.52 | $4.0B |
| ZLAB | Zai Lab Limited | $26.23 | $3.0B |
| AAPG | Ascentage Pharma Group International | $17.62 | $1.6B |
| RARE | Ultragenyx Pharmaceutical Inc. | $15.30 | $1.5B |