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- Se ha administrado la primera dosis a los pacientes en el estudio clínico VIRAGE2 de Fase IIa, que evalúa la administración con mayor frecuencia de VCN-01 (zabilugene almadenorepvec), cuyo objetivo es mejorar los resultados del tratamiento en pacientes con adenocarcinoma ductal pancreático (PDAC) metastásico - - Efectivo y equivalentes de efectivo por valor de 11,3 millones de dólares estadounidenses a 30 de junio de 2026, con liquidez suficiente hasta el primer trimestre de 2027 - ROCKVILLE, Maryland, Aug.
– First patients dosed in the VIRAGE2 Phase 2a clinical study evaluating more frequent repeated dosing of VCN-01 (zabilugene almadenorepvec) the goal of which is to improve treatment outcomes in metastatic pancreatic ductal adenocarcinoma (PDAC) patients – – Cash and cash equivalents of $11.3 million as of June 30, 2026; cash runway into Q1 2027 – ROCKVILLE, Md., Aug. 11, 2026 (GLOBE NEWSWIRE) -- Theriva™ Biologics, Inc. (NYSE American: TOVX), a diversified clinical-stage company developing therapeutics designed to treat cancer and related diseases in areas of high unmet need, today reported financial results for the second quarter ended June 30, 2026, and provided a corporate update.
- VIRAGE2 exploratory study designed to refine the VCN-01 dosing regimen for potential evaluation in a future pivotal Phase 3 clinical trial in metastatic pancreatic ductal adenocarcinoma (PDAC) -
- VIRAGE2 exploratory study designed to refine dosing regimen to potentially improved outcomes in a future pivotal Phase 3 clinical trial - - Study builds on positive clinical data from the recent VIRAGE study and feedback from the EMA and FDA recognizing the potential of repeated VCN-01 dosing to provide clinical benefit - ROCKVILLE, Md., July 07, 2026 (GLOBE NEWSWIRE) -- Theriva™ Biologics (NYSE American: TOVX), a diversified clinical-stage company developing therapeutics designed to treat cancer and related diseases in areas of high unmet need, today announced that the Spanish Agency of Medicines and Medical Devices (AEMPS) has authorized the Company to initiate the VIRAGE2 clinical trial, entitled ”A Phase IIa, single-arm, single-center, open-label, proof-of-concept trial evaluating increased frequency dosing of zabilugene almadenorepvec (VCN-01) in combination with gemcitabine/nab-paclitaxel in patients with newly-diagnosed metastatic pancreatic cancer” (EUCT: 2026-525566-21-00).
– Prolonged overall survival (OS) was observed in heavily pre-treated refractory Head & Neck Squamous Cell Carcinoma (HNSCC) patients administered IV VCN-01 prior to the immune checkpoint inhibitor durvalumab –
- Prolonged overall survival (OS) was observed in heavily pre-treated refractory Head and Neck Squamous Cell Carcinoma (HNSCC) patients administered IV VCN-01 prior to the immune checkpoint inhibitor durvalumab - - Pharmacokinetic, tissue biopsy, radiomic and transcriptomic results all support the proposed VCN-01 stroma-degrading and immune enhancing modes-of-action and resensitization of refractory tumors to durvalumab - - Increased levels of PD-L1 positive T-cells and other biomarkers were found in patients after sequential administration of VCN-01 and durvalumab, consistent with reactivation of immune responses - ROCKVILLE, Md.
– Alignment with the FDA on the Phase 3 trial design of VCN-01 (zabilugene almadenorepvec) for treatment of metastatic pancreatic ductal adenocarcinoma (PDAC) –
- Los análisis de la respuesta tumoral, los biomarcadores y los subgrupos del ensayo clínico VIRAGE de Fase 2b respaldan el mecanismo de acción inmunomediado de VCN-01 y demuestran una mejora en los resultados de los pacientes tratados con VCN-01 en múltiples subgrupos, incluidos los pacientes con metástasis hepáticas - - Los datos se facilitarán en un póster durante la Reunión Anual de la Asociación Americana para la Investigación del Cáncer (AACR) en San Diego, California, el lunes 20 de abril de 2026 - ROCKVILLE, Maryland, April 18, 2026 (GLOBE NEWSWIRE) -- Theriva Biologics (NYSE American: TOVX), («Theriva» o la «Empresa»), una empresa diversificada en fase clínica que desarrolla terapias diseñadas para tratar el cáncer y enfermedades relacionadas en áreas con grandes necesidades médicas no cubiertas, ha anunciado hoy la próxima presentación en póster de nuevos datos y análisis de subgrupos del ensayo clínico VIRAGE de Fase 2b, que evalúa VCN-01 (zabilugene almadenorepvec) más gemcitabina/nab-paclitaxel en pacientes con cáncer de páncreas metastásico de nuevo diagnóstico.