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| SRRKSRRKScholar Rock Holding Corporation | Scholar Rock Holding Corporation | $41.49 | $5.1B |
| HTFLHTFLHeartflow, Inc. Common Stock | Heartflow, Inc. Common Stock | $56.71 | $4.9B |
| FOLDFOLDAmicus Therapeutics, Inc. | Amicus Therapeutics, Inc. | $14.49 | $4.5B |
| LIVNLIVNLivaNova PLC | LivaNova PLC | $80.90 | $4.4B |
| TARSTARSTarsus Pharmaceuticals, Inc. | Tarsus Pharmaceuticals, Inc. | $68.20 | $3.2B |
| HCMHCMHUTCHMED (China) Limited | HUTCHMED (China) Limited | $14.36 | $2.6B |
| BHCBHCBausch Health Companies Inc. | Bausch Health Companies Inc. | $6.44 | $2.4B |
| SUPNSUPNSupernus Pharmaceuticals, Inc. | Supernus Pharmaceuticals, Inc. | $40.70 | $2.4B |
| SGRYSGRYSurgery Partners, Inc. | Surgery Partners, Inc. | $15.75 | $2.1B |
| ATECATECAlphatec Holdings, Inc. | Alphatec Holdings, Inc. | $11.11 | $1.7B |