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This fund primarily allocates capital to equity investments, specifically common and preferred shares, across companies of all market capitalizations. Under typical market conditions, at least 80% of its net assets, along with any borrowed capital used for investment, will be directed toward firms predominantly active in the healthcare industry. These healthcare companies are defined as those primarily involved in the research, development, production, or distribution of healthcare-related products and services. The portfolio maintains a non-diversified investment approach.

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Revolution Medicines was a top contributor during the quarter. AbbVie, by contrast, traded largely sideways, as investors continued to assess its post-patent earnings durability. While Eli Lilly delivered strong absolute performance — driven by continued GLP-1 demand and the FDA approval of Zepbound — our underweight position in the name was a significant detractor from relative results. During the quarter, we purchased Avidity Biosciences, a clinical-stage biopharma company focused on RNA therapies for rare muscle diseases, and Abivax SA, a clinical-stage biopharma company focused on chronic inflammatory diseases.

During the fourth quarter, the Harbor Health Care ETF returned 10.43% (NAV), underperforming the Russell 3000® Growth Health Care Index, which returned 16.71%. The underperformance was primarily driven by stock selection and relative underexposure to higher-beta names, particularly within development-stage biotechnology and more speculative areas of medtech. From a factor perspective, the ETF's overweight exposure to volatility was the largest tailwind to relative performance, offsetting a headwind from an underweight exposure to size.

During the third quarter, the Harbor Health Care ETF returned 7.30% (NAV), outperforming the Russell 3000® Growth Health Care Index, which returned 3.80%. We purchased IDEXX Laboratories, a MedTech company primarily focused on veterinary services, with a strong market position, steady end markets, and a strong growth profile, in our opinion. We sold Verona Therapeutics, a commercial stage biopharma company focused on lung disease, when the stock hit our price target following the announcement that Merck would be acquiring the company.