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| SRRK | Scholar Rock Holding Corporation | $55.67 | $6.7B |
| CGON | CG Oncology Inc. | $72.00 | $6.4B |
| XENE | Xenon Pharmaceuticals Inc. | $58.80 | $5.7B |
| CELC | Celcuity Inc. | $85.49 | $4.2B |
| ADPT | Adaptive Biotechnologies Corporation | $24.23 | $3.9B |
| IDYA | IDEAYA Biosciences, Inc. | $37.45 | $3.6B |
| TARS | Tarsus Pharmaceuticals, Inc. | $81.12 | $3.5B |
| IRON | Disc Medicine, Inc. | $74.14 | $2.8B |
| ZLAB | Zai Lab Limited | $24.17 | $2.7B |
| AAPG | Ascentage Pharma Group International | $16.67 | $1.5B |