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| SRRK | Scholar Rock Holding Corporation | $55.41 | $6.6B |
| KNSA | Kiniksa Pharmaceuticals International, plc | $76.27 | $5.8B |
| CDTX | Cidara Therapeutics, Inc. | $221.38 | $5.6B |
| ADPT | Adaptive Biotechnologies Corporation | $24.20 | $3.9B |
| CPRX | Catalyst Pharmaceuticals, Inc. | $31.49 | $3.9B |
| IDYA | IDEAYA Biosciences, Inc. | $37.59 | $3.6B |
| MLYS | Mineralys Therapeutics, Inc. | $28.20 | $2.5B |
| SUPN | Supernus Pharmaceuticals, Inc. | $41.64 | $2.4B |
| BHC | Bausch Health Companies Inc. | $5.86 | $2.2B |
| PRGO | Perrigo Company plc | $13.59 | $1.9B |