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| IOVAIOVAIovance Biotherapeutics, Inc. | Iovance Biotherapeutics, Inc. | $14.09 | $6.4B |
| MBXMBXMBX Biosciences, Inc. Common Stock | MBX Biosciences, Inc. Common Stock | $48.50 | $2.3B |
| MRVIMRVIMaravai LifeSciences Holdings, Inc. | Maravai LifeSciences Holdings, Inc. | $7.32 | $2.1B |
| VIRVIRVir Biotechnology, Inc. | Vir Biotechnology, Inc. | $10.57 | $1.8B |
| REPLREPLReplimune Group, Inc. | Replimune Group, Inc. | $11.46 | $1.1B |
| AVBPAVBPArriVent BioPharma, Inc. | ArriVent BioPharma, Inc. | $21.00 | $1.0B |
| MGTXMGTXMeiraGTx Holdings plc | MeiraGTx Holdings plc | $9.21 | $884.6M |
| ATXSATXSAstria Therapeutics, Inc. | Astria Therapeutics, Inc. | $12.58 | $718.1M |
| VALNVALNValneva SE | Valneva SE | $5.26 | $498.8M |
| ARVNARVNArvinas, Inc. | Arvinas, Inc. | $7.30 | $471.0M |