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| PRAXPRAXPraxis Precision Medicines, Inc. | Praxis Precision Medicines, Inc. | $267.59 | $7.5B |
| DFTXDFTXDefinium Therapeutics, Inc. | Definium Therapeutics, Inc. | $37.08 | $5.0B |
| ACADACADAcadia Pharmaceuticals Inc. | Acadia Pharmaceuticals Inc. | $20.17 | $3.5B |
| DNLIDNLIDenali Therapeutics Inc. | Denali Therapeutics Inc. | $19.22 | $3.1B |
| HRMYHRMYHarmony Biosciences Holdings, Inc. | Harmony Biosciences Holdings, Inc. | $37.95 | $2.2B |
| GHRSGHRSGH Research PLC | GH Research PLC | $20.02 | $1.4B |
| RAPPRAPPRapport Therapeutics, Inc. Common Stock | Rapport Therapeutics, Inc. Common Stock | $27.54 | $1.3B |
| LBRXLBRXLB Pharmaceuticals Inc Common Stock | LB Pharmaceuticals Inc Common Stock | $39.64 | $1.3B |
| MPLTMPLTMapLight Therapeutics, Inc. | MapLight Therapeutics, Inc. | $8.17 | $348.2M |
| NERVNERVMinerva Neurosciences, Inc. | Minerva Neurosciences, Inc. | $2.23 | $106.5M |