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| APGE | Apogee Therapeutics, Inc. | $134.20 | $8.3B |
| CNTA | Centessa Pharmaceuticals plc | $40.50 | $6.3B |
| XENE | Xenon Pharmaceuticals Inc. | $66.74 | $5.3B |
| TVTX | Travere Therapeutics, Inc. | $56.58 | $5.3B |
| CELC | Celcuity Inc. | $91.69 | $4.5B |
| LEGN | Legend Biotech Corporation | $23.54 | $4.4B |
| IRON | Disc Medicine, Inc. | $75.58 | $2.9B |
| RARE | Ultragenyx Pharmaceutical Inc. | $28.62 | $2.8B |
| TARS | Tarsus Pharmaceuticals, Inc. | $57.26 | $2.5B |
| AAPG | Ascentage Pharma Group International | $19.10 | $1.8B |