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| APGE | Apogee Therapeutics, Inc. | $134.08 | $8.3B |
| CNTA | Centessa Pharmaceuticals plc | $40.50 | $6.3B |
| CGON | CG Oncology Inc. | $69.31 | $6.1B |
| TVTX | Travere Therapeutics, Inc. | $56.26 | $5.2B |
| XENE | Xenon Pharmaceuticals Inc. | $66.18 | $5.2B |
| LEGN | Legend Biotech Corporation | $23.53 | $4.4B |
| IRON | Disc Medicine, Inc. | $74.32 | $2.8B |
| RARE | Ultragenyx Pharmaceutical Inc. | $27.65 | $2.7B |
| ZLAB | Zai Lab Limited | $20.50 | $2.3B |
| AAPG | Ascentage Pharma Group International | $19.24 | $1.8B |