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| LLYLLYEli Lilly and Company | Eli Lilly and Company | $1,273.46 | $1.2T |
| AZNAZNAstraZeneca PLC | AstraZeneca PLC | $171.49 | $266.0B |
| AMGNAMGNAmgen Inc. | Amgen Inc. | $439.26 | $237.5B |
| PFEPFEPfizer Inc. | Pfizer Inc. | $30.03 | $171.2B |
| VRTXVRTXVertex Pharmaceuticals Incorporated | Vertex Pharmaceuticals Incorporated | $523.93 | $132.8B |
| REGNREGNRegeneron Pharmaceuticals, Inc. | Regeneron Pharmaceuticals, Inc. | $805.02 | $82.9B |
| ALNYALNYAlnylam Pharmaceuticals, Inc. | Alnylam Pharmaceuticals, Inc. | $224.03 | $30.0B |
| UTHRUTHRUnited Therapeutics Corporation | United Therapeutics Corporation | $587.50 | $25.2B |
| IONSIONSIonis Pharmaceuticals, Inc. | Ionis Pharmaceuticals, Inc. | $42.93 | $7.1B |
| PTCTPTCTPTC Therapeutics, Inc. | PTC Therapeutics, Inc. | $60.59 | $5.1B |