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| NBIXNBIXNeurocrine Biosciences, Inc. | Neurocrine Biosciences, Inc. | $142.70 | $14.5B |
| JAZZJAZZJazz Pharmaceuticals plc | Jazz Pharmaceuticals plc | $214.00 | $13.9B |
| PRAXPRAXPraxis Precision Medicines, Inc. | Praxis Precision Medicines, Inc. | $252.96 | $7.1B |
| DFTXDFTXDefinium Therapeutics, Inc. | Definium Therapeutics, Inc. | $35.67 | $4.8B |
| XENEXENEXenon Pharmaceuticals Inc. | Xenon Pharmaceuticals Inc. | $35.34 | $3.4B |
| DNLIDNLIDenali Therapeutics Inc. | Denali Therapeutics Inc. | $18.41 | $2.9B |
| SUPNSUPNSupernus Pharmaceuticals, Inc. | Supernus Pharmaceuticals, Inc. | $40.70 | $2.4B |
| RAPPRAPPRapport Therapeutics, Inc. Common Stock | Rapport Therapeutics, Inc. Common Stock | $25.93 | $1.2B |
| AVXLAVXLAnavex Life Sciences Corp. | Anavex Life Sciences Corp. | $1.33 | $123.3M |
| NMRANMRANeumora Therapeutics, Inc. Common Stock | Neumora Therapeutics, Inc. Common Stock | $0.38 | $71.3M |