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| IONSIONSIonis Pharmaceuticals, Inc. | Ionis Pharmaceuticals, Inc. | $42.93 | $7.1B |
| PRAXPRAXPraxis Precision Medicines, Inc. | Praxis Precision Medicines, Inc. | $252.96 | $7.1B |
| DNLIDNLIDenali Therapeutics Inc. | Denali Therapeutics Inc. | $18.41 | $2.9B |
| PRTAPRTAProthena Corporation plc | Prothena Corporation plc | $8.20 | $421.0M |
| ACIUACIUAC Immune S.A. | AC Immune S.A. | $2.42 | $246.3M |
| ELDNELDNEledon Pharmaceuticals, Inc. | Eledon Pharmaceuticals, Inc. | $2.30 | $186.9M |
| AVXLAVXLAnavex Life Sciences Corp. | Anavex Life Sciences Corp. | $1.33 | $123.3M |
| PMNPMNProMIS Neurosciences, Inc. | ProMIS Neurosciences, Inc. | $8.34 | $74.8M |
| CLNNCLNNClene Inc. | Clene Inc. | $3.88 | $55.2M |
| NRSNNRSNNeuroSense Therapeutics Ltd. | NeuroSense Therapeutics Ltd. | $2.46 | $4.7M |