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Medicare's new GLP-1 coverage could expand access to weight-loss drugs, making ETFs a diversified way to tap growth across the obesity treatment market.
With AI and space dominating many of the market's most popular investment themes, it can be difficult to find differentiated opportunities. Healthcare is often viewed as one of the more defensive sectors, supported by relatively steady demand regardless of the economic environment.
GLP-1 drugs are reshaping healthcare and consumer markets. These ETFs offer targeted exposure to the booming obesity-drug trend.
Eli Lilly and Novo Nordisk are accelerating global obesity pill launches as rising GLP-1 demand puts weight-loss ETFs in focus.
Roundhill GLP-1 and Weight Loss ETF (NASDAQ: OZEM - Get Free Report) saw a significant increase in short interest in April. As of April 15th, there was short interest totaling 35,481 shares, an increase of 345.5% from the March 31st total of 7,964 shares. Currently, 2.1% of the company's stock are short sold. Based on an
Weight loss drugs are big business, with the GLP-1 receptor agonist market expected to nearly triple in size to $185 billion by 2033, a compound annual growth rate of about 12.4%. Although increasingly a global medical phenomenon, the bulk of the market still exists in the United States, and domestic investors can get in on the action by targeting companies that manufacture these powerful drugs.
For the past two years, GLP-1 medications have been a fixture of consumer trend analysis, discussed by everyone from CNBC to sell-side strategists to management consultants. Real apparel expenditure outperformed total consumer spending by approximately 400 basis points per month on average in 2025, a trend our analysis attributes in part to GLP-1-driven wardrobe replacement. The oral pill launch likely means the population of GLP-1 users will grow materially over the next several years.
Roundhill GLP-1 and Weight Loss ETF (NASDAQ: OZEM - Get Free Report) was the recipient of a large increase in short interest during the month of January. As of January 30th, there was short interest totaling 44,401 shares, an increase of 47.1% from the January 15th total of 30,184 shares. Approximately 2.7% of the shares of
SEC filings for OZEM aren't indexed yet — common for recently launched funds. Browse the issuer's filings on SEC EDGAR directly.